UNIT - 1

Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate

General methods of preparation, assay for the compounds superscripted with afterisk , properties and medicinal uses of inorganic compounds belonging to the following classes. 

UNIT - 2

Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.

Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance.

Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.

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UNIT - 3

Gastrointestinal agents 

Acidifiers: Ammonium chloride* and Dil. HCI

Antacid: Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture. 

Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite

Antimicrobials: Mechanism, classification, Potassiu permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*, lodine and its preparations. 

UNIT - 4

Miscellaneous compounds

Expectorants: Potassium iodide, Ammonium chloride.

Emetics: Copper sulphate*, Sodium potassium tartarate

Haematinics: Ferrous sulphate, Ferrous gluconate

Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333

Astringents: Zinc Sulphate, Potash Alum

UNIT - 5

Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of a, B, y radiations, Half life, radio isotopes and study of radio isotopes - Sodium iodide 1131, Storage conditions, precautions & pharmaceutical application of radioactive substances.

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